Charles J Lockwood Selected Research

Uterine Hemorrhage (Uterine Bleeding)

6/2017	Thrombin impairs human endometrial endothelial angiogenesis; implications for progestin-only contraceptive-induced abnormal uterine bleeding.
1/2016	The role of decidual cells in uterine hemostasis, menstruation, inflammation, adverse pregnancy outcomes and abnormal uterine bleeding.
3/2015	Mass spectrometry identification of potential mediators of progestin-only contraceptive-induced abnormal uterine bleeding in human endometrial stromal cells.
1/2015	Progestins Upregulate FKBP51 Expression in Human Endometrial Stromal Cells to Induce Functional Progesterone and Glucocorticoid Withdrawal: Implications for Contraceptive- Associated Abnormal Uterine Bleeding.
4/2010	Long-term progestin contraceptives (LTPOC) induce aberrant angiogenesis, oxidative stress and apoptosis in the guinea pig uterus: A model for abnormal uterine bleeding in humans.
2/2009	Decidualized human endometrial stromal cells mediate hemostasis, angiogenesis, and abnormal uterine bleeding.
2/2007	The role of decidualization in regulating endometrial hemostasis during the menstrual cycle, gestation, and in pathological states.
11/2005	Tibolone and its metabolites enhance tissue factor and PAI-1 expression in human endometrial stromal cells: Evidence of progestogenic effects.
3/2004	Effects of thrombin, hypoxia, and steroids on interleukin-8 expression in decidualized human endometrial stromal cells: implications for long-term progestin-only contraceptive-induced bleeding.
11/2003	Progestin-regulated expression of tissue factor in decidual cells: implications in endometrial hemostasis, menstruation and angiogenesis.

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Charles J Lockwood Research Topics

Disease

22	Pre-Eclampsia (Preeclampsia) 01/2022 - 03/2005
20	Hemorrhage 12/2017 - 09/2002
13	Inflammation (Inflammations) 01/2019 - 03/2004
11	Endometriosis 01/2021 - 04/2008
11	Uterine Hemorrhage (Uterine Bleeding) 06/2017 - 09/2002
9	Infections 01/2022 - 02/2006
9	Rupture 01/2020 - 12/2004
9	Premature Birth (Birth, Premature) 01/2020 - 11/2003
8	Hypoxia (Hypoxemia) 03/2015 - 09/2002
7	Chorioamnionitis 12/2015 - 09/2005
7	Thrombophilia 03/2011 - 02/2002
6	Preterm Premature Rupture of the Membranes 01/2020 - 07/2005
5	Abruptio Placentae (Placental Abruption) 01/2016 - 09/2005
4	Neoplasms (Cancer) 01/2020 - 02/2010
4	Fetal Growth Retardation (Intrauterine Growth Retardation) 11/2015 - 02/2007
2	COVID-19 01/2022 - 11/2021
2	Thrombosis (Thrombus) 01/2022 - 02/2002
2	Infertility (Sterility) 03/2018 - 04/2012
2	Stillbirth 01/2018 - 09/2010
2	Macular Degeneration (Age-Related Maculopathy) 02/2017 - 02/2010
2	Ischemia 01/2016 - 03/2004
2	Major Depressive Disorder (Major Depressive Disorders) 09/2012 - 11/2011
2	Proteinuria 07/2008 - 05/2006
2	Thromboembolism 09/2007 - 02/2002
2	Premature Obstetric Labor (Premature Labor) 04/2007 - 06/2006
2	Activated Protein C Resistance (APC Resistance) 02/2004 - 12/2003
2	Hyperhomocysteinemia 02/2004 - 02/2002
1	Leiomyoma (Uterine Fibroids) 01/2022
1	Pregnancy Complications 01/2022
1	Cytokine Release Syndrome 01/2022
1	Obesity 01/2020
1	Chronic Pain 03/2018
1	Burns 03/2018

Drug/Important Bio-Agent (IBA)

28	Thrombin FDA Link 01/2020 - 09/2002
18	CytokinesIBA 01/2022 - 08/2005
16	Progestins (Progestagens)IBA 12/2017 - 09/2002
15	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2019 - 12/2003
13	Thromboplastin (Tissue Factor)IBA 01/2020 - 07/2005
12	Proteins (Proteins, Gene)FDA Link 01/2022 - 09/2002
10	Contraceptive Agents (Contraceptives)IBA 06/2017 - 09/2002
9	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 02/2017 - 09/2002
8	Progesterone FDA LinkGeneric 01/2016 - 03/2004
7	Messenger RNA (mRNA)IBA 01/2022 - 09/2002
7	Matrix Metalloproteinases (MMPs)IBA 01/2016 - 07/2005
7	Interleukin-1beta (Interleukin 1 beta)IBA 08/2009 - 02/2006
6	ChemokinesIBA 01/2022 - 11/2010
6	Interleukin-8 (Interleukin 8)IBA 07/2009 - 03/2004
5	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 01/2020 - 05/2009
5	Plasminogen Activator Inhibitor 1IBA 01/2016 - 11/2005
5	Hemostatics (Antihemorrhagics)IBA 04/2011 - 08/2005
4	InterferonsIBA 01/2019 - 09/2014
4	Factor VII (Proconvertin)IBA 06/2011 - 03/2004
3	SteroidsIBA 01/2022 - 09/2002
3	Interleukin-6 (Interleukin 6)IBA 01/2022 - 06/2008
3	Interleukin-11 (Interleukin 11)IBA 01/2022 - 09/2005
3	Immunoconjugates (Immunoconjugate)IBA 12/2020 - 02/2010
3	Prothrombin (Factor II)IBA 06/2017 - 02/2002
3	Progesterone Receptors (Progesterone Receptor)IBA 01/2016 - 02/2008
3	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 06/2012 - 02/2006
3	Heparin (Liquaemin)FDA LinkGeneric 12/2011 - 02/2002
3	Reactive Oxygen Species (Oxygen Radicals)IBA 04/2011 - 09/2002
3	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 08/2009 - 03/2005
2	Small Interfering RNA (siRNA)IBA 01/2022 - 10/2011
2	EnzymesIBA 01/2021 - 01/2019
2	MicroRNAs (MicroRNA)IBA 01/2020 - 02/2016
2	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2019 - 01/2016
2	Interleukin-1 (Interleukin 1)IBA 01/2019 - 11/2010
2	RNA (Ribonucleic Acid)IBA 01/2018 - 02/2016
2	GlucocorticoidsIBA 12/2016 - 01/2015
2	Proteinase-Activated ReceptorsIBA 01/2016 - 09/2011
2	tiboloneIBA 05/2015 - 11/2005
2	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 06/2012 - 09/2011
2	Tyrosine (L-Tyrosine)FDA Link 12/2011 - 04/2007
2	Antiphospholipid AntibodiesIBA 11/2011 - 09/2010
2	A-factor (Streptomyces)IBA 10/2011 - 06/2011
2	hI-con1IBA 10/2011 - 06/2011
2	Angiopoietin-2IBA 04/2011 - 02/2009
2	Vascular Endothelial Growth Factor Receptor-1 (fms-Like Tyrosine Kinase)IBA 07/2009 - 03/2005
2	Angiopoietin-1IBA 02/2009 - 09/2002
2	CreatinineIBA 07/2008 - 05/2006
2	Plasminogen InactivatorsIBA 04/2007 - 02/2002
2	Peptide Hydrolases (Proteases)FDA Link 02/2007 - 11/2005
2	Levonorgestrel (Plan B)FDA LinkGeneric 03/2004 - 11/2003
2	factor V LeidenIBA 02/2004 - 02/2002
2	AnticoagulantsIBA 02/2004 - 02/2002
1	Viral RNAIBA 01/2022
1	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 11/2021
1	Cytochrome P-450 CYP1A1 (CYP1A1)IBA 01/2021
1	2-hydroxyestradiolIBA 01/2021
1	p38 Mitogen-Activated Protein KinasesIBA 01/2021
1	4-hydroxyestradiolIBA 01/2021
1	Propranolol (Inderal)FDA LinkGeneric 01/2021
1	Cell-Free Nucleic AcidsIBA 01/2019
1	LigandsIBA 01/2019
1	ImmunosorbentsIBA 01/2019
1	PowdersIBA 03/2018

Therapy/Procedure

7	Therapeutics 02/2017 - 02/2002
4	Contraception (Birth Control) 01/2020 - 09/2002
2	Immunotherapy 10/2011 - 06/2011
1	Intraperitoneal Injections 03/2018